Genotype and phenotype of COVID-19: Their roles in pathogenesis
Identifieur interne : 000190 ( Main/Exploration ); précédent : 000189; suivant : 000191Genotype and phenotype of COVID-19: Their roles in pathogenesis
Auteurs : Leila Mousavizadeh [Allemagne] ; Sorayya Ghasemi [Iran]Source :
- Journal of Microbiology, Immunology, and Infection [ 1684-1182 ] ; 2020.
Abstract
COVID-19 is a novel coronavirus with an outbreak of unusual viral pneumonia in Wuhan, China, and then pandemic. Based on its phylogenetic relationships and genomic structures the COVID-19 belongs to genera Betacoronavirus. Human Betacoronaviruses (SARS-CoV-2, SARS-CoV, and MERS-CoV) have many similarities, but also have differences in their genomic and phenotypic structure that can influence their pathogenesis. COVID-19 is containing single-stranded (positive-sense) RNA associated with a nucleoprotein within a capsid comprised of matrix protein. A typical CoV contains at least six ORFs in its genome. All the structural and accessory proteins are translated from the sgRNAs of CoVs. Four main structural proteins are encoded by ORFs 10, 11 on the one-third of the genome near the 3′-terminus. The genetic and phenotypic structure of COVID-19 in pathogenesis is important. This article highlights the most important of these features compared to other Betacoronaviruses.
Url:
DOI: 10.1016/j.jmii.2020.03.022
PubMed: 32265180
PubMed Central: 7138183
Affiliations:
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xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Virus-host Interaction, Heinrich-Pette-Institut (HPI), Martinistrasse 52, 20251 Hamburg</wicri:regionArea><wicri:noRegion>20251 Hamburg</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Ghasemi, Sorayya" sort="Ghasemi, Sorayya" uniqKey="Ghasemi S" first="Sorayya" last="Ghasemi">Sorayya Ghasemi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord</wicri:regionArea><wicri:noRegion>Shahrekord</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord</wicri:regionArea><wicri:noRegion>Shahrekord</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Microbiology, Immunology, and Infection</title><idno type="ISSN">1684-1182</idno><idno type="eISSN">1995-9133</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>COVID-19 is a novel coronavirus with an outbreak of unusual viral pneumonia in Wuhan, China, and then pandemic. Based on its phylogenetic relationships and genomic structures the COVID-19 belongs to genera Betacoronavirus. Human Betacoronaviruses (SARS-CoV-2, SARS-CoV, and MERS-CoV) have many similarities, but also have differences in their genomic and phenotypic structure that can influence their pathogenesis. COVID-19 is containing single-stranded (positive-sense) RNA associated with a nucleoprotein within a capsid comprised of matrix protein. A typical CoV contains at least six ORFs in its genome. All the structural and accessory proteins are translated from the sgRNAs of CoVs. Four main structural proteins are encoded by ORFs 10, 11 on the one-third of the genome near the 3′-terminus. The genetic and phenotypic structure of COVID-19 in pathogenesis is important. This article highlights the most important of these features compared to other Betacoronaviruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. 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Menachery</name></author><author><name sortKey="Gralinski, L E" uniqKey="Gralinski L">L.E. Gralinski</name></author><author><name sortKey="Case, J B" uniqKey="Case J">J.B. Case</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez, M A" uniqKey="Martinez M">M.A. Martinez</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Iran</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li></settlement></list><tree><country name="Allemagne"><region name="Hambourg"><name sortKey="Mousavizadeh, Leila" sort="Mousavizadeh, Leila" uniqKey="Mousavizadeh L" first="Leila" last="Mousavizadeh">Leila Mousavizadeh</name></region></country><country name="Iran"><noRegion><name sortKey="Ghasemi, Sorayya" sort="Ghasemi, Sorayya" uniqKey="Ghasemi S" first="Sorayya" last="Ghasemi">Sorayya Ghasemi</name></noRegion><name sortKey="Ghasemi, Sorayya" sort="Ghasemi, Sorayya" uniqKey="Ghasemi S" first="Sorayya" last="Ghasemi">Sorayya Ghasemi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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